You can find out what the property *should* be doing using a number of the STR data subscription services (none are perfect, but the overall trend is usually correct), or from getting projections from some of the larger, (or not necessarily larger, but more tech-forward) management companies, and also using the ENEMY MethodCovid has actually caused a boom in true, regional vacation rental markets, as most tourists aren't comfortable getting on planes or going to large metro areas yet.

I have heard that Columbus, Indianapolis, and a lot of the states in the Central Region have been good areas to invest in.

I was also curious about the best locations to house hack if there are any (could be a specific location or just a general region).

There are a lot of regional Insurance companies that can be very competitive in the markets they service. 

I've found regional credit unions to be a good place for flexible terms and reasonable rates.

Now that I’m interested, unexpectedly my extended family has decided to sell their largest real estate holding: a 6 bedroom 4 bath, 3 story home in the Pacific Heights neighborhood of SF.

Move-in fee, no.It must be a regional thing.

Your best bet will be smaller, regional banks or CU's.Lastly, for analysis you can also look at cap rates.  

We rent to a health corporation that services a region the size of Minnesota.

I am looking at a property with federal pacific breaker boxes.