I do have cash flow from my current job however, I am recently married and about to become a dad in a couple of months.

I am looking at more LTR of SF, MF or commercial properties in markets that cash flow well.

Does this affect a cash-out refinance or pulling out equity in the form of a HELOC/equity loan? 

They paid full market value (or more), they paid cash and closed in two weeks, so if you own some houses and you want to sell them, they'll be a good buyer for you.Now, if you are looking to do very large multifamily deals, that's a different story, but I'm not thinking that is the direction you are suggesting.

Cashed out on a primary to buy an investment when the rates were good.

Would I still be able to cash out refinance the 25% DP I put down (assuming lender does 75% LTV cash out refinances)?

You've been able to save up and have $50K in liquid cash.   

Does this affect a cash-out refinance or pulling out equity in the form of a HELOC/equity loan?

Anyone having major success with only buying SFH and renting them out to tenants to make good cash flow each month and re-investing?

People offer to pay cash up front or rent for a longer term in hopes of avoiding any scrutiny.