I'm particularly interested in cash flow + long-term appreciation, but I'm also open to short-term gains if the opportunity is right.Any insights, personal experiences, or advice would be greatly appreciated!

Interest rates have doubled in last 2.5 years.  

Are there any companies in Spain that help with long-distance investment properties? 

Hey Connor the way I look at it is depending on what your plan is with the property, if you plan to keep it for the long term and the numbers work (Cash flow, equity, Appreciation etc) then negotiate a price you are comfortable with and go for it.

In a wholesale situation, the F.B.I. looks at all parties involved, does not care that you didn't know and can ruin your life for a long time to come.  

I hate to rain on this parade but I haven’t seen a property trade at a 10-cap in Syracuse in the last twelve months.

I have been an Expat living and investing part time and now full time in Bocas del Toro for the last 25 years.

Trying to keep a long story short here.

And if I sell it why does it make more sense in the long run, and at what price should I sell it for if it’s appraised for less than I bought it with current market. 

Over the last 5 years you're looking at a Compounded Annual Growth Rate (CAGR) of just 3.11%.