I like Cleveland for lower-cost, cashflowing property (as much as I am biased being an agent here).

Call me biased (I own a management company) but self management is one of the worst decisions one can make.

Sample Bias!

The answer may be biased depending on the size of the MFH.

YES, we may be a little biased, but check out our blog here on BP comparing Detroit to other cities and Deep Dives on Metro Detroit cities & neighborhoods: https://www.biggerpockets.com/...

I may be biased, but often times people forget about Puerto Rico and the US Virgin Islands. 

I am biased because I work/play/invest here but I work with a lot of out-of-state investors that are looking to do the same thing as yourself.

While the class systems are arbitrary and can be biased based on the person classifying the areas, you are correct thatusually classes A/B make more on appreciation, but barely cash flow (especially with the current interest rates), and that in C classes, you can generate some cash flow. but appreciation rates may be slightly slower if your main focus would be to build equity with some nice monthly income from rent ($50-$100 cash flow after accounting for expenses) It would be in a C class neighborhood with higher crime rates in my market of the KC metro.

I'm probably a biased opinion, and you can just buy something.

Even if a 6plex should sell based on cap rates it might be too close to a 4plex and getting some comparable bias?