Meaning you mathematically adjust for the higher overhead costs; if you have a bigger rent payment due at the beginning of the month, then you need to be making more cash flow to accommodate the additional risk.

Our house should accommodate either with plenty of off-street parking, a separate basement entrance, and is an owner-occupied residence for the city STR compliance. 

In addition, the owner of the home must not own more than three single-family homes.3) They are unable to provide sufficient documentation, such as the emotional support animal letter, that verifies the ESA is necessary for their health and well-being.4) The tenant provides fraudulent documentation attesting to their need for an emotional support animal (usually a fake emotional support animal letter).5) The landlord can demonstrate that making accommodations for an ESA would impose undue financial burden or logistical burden. 6) The animal is destructive to the property or displays threatening behaviors that could put other tenants or yourself at risk.7) The size or nature of the animal makes it impossible to house safely or humanely. 

Are there any special arrangements you need to accommodate for any of the residents (transportation in general, trips for dialysis, monitoring blood sugar levels, etc.)?

I think you'd be surprised how much more money a dog owner will pay to make sure their pet has nice accommodations also.

If not, can you up your down to accommodate the commission?

If you plug the numbers into the calculator are you having the rate be refinanced at a half percentage or 1% higher to accommodate for rising rates in the future to make sure the numbers work in the future as well?

Despite the possibility of higher interest rates, they can have more accommodating qualifying requirements.If you currently own homes with a sizable amount of equity, you may be able to get funds for your down payment through a cash-out refinancing or a home equity line of credit (HELOC).

I believe you would need to think first about parking - can it accommodate 6 cars with a combination or driveway and street parking?

If your property is legally allowed as an STR, then it's just a simple form to get the permit and pay the taxes (not only General Excise Tax as mentioned above but also Transient Accommodation Taxes for both the county and state).The second is a bit trickier and that's making sure that the property is legally allowed as an STR.