Finding the right market is key since every area has its own unique dynamics.

The unique architecture and potential of the property, as well as the money making potential that it had.

I have been buying a small pharma company in the opthalmic space, Harrow, HROW since May at $10, with good growth prospects and in an area with long horizon of medical need for the diseases it treats, they keep announcing better earnings each quarter, and stock now $44 in just 3-4 months, I've bought other companies with good products in the past like NVidia back in 2009 as they made the best graphics chip, G-Force, for gaming.

part of a current medical campus? 

I have a 1/1 and a 2/1 and although I'm seeing lots of different types of travelers, the ones who have been booking my place have all been traveling medical professionals.

Yes, because Private Money infers that you are in a negotiable deal where your project can be outside the box and you can negotiate unique terms with a private individual - that - or a big box lender with strict rules and guidelines. 

STRs have unique tax considerations, so setting up the right systems early will save you headaches down the road!

You'll likely find it easy to find people who will tell you what you want to hear, but you really need hard facts not speculation.But for some speculation, if you're talking about the Nantahala River or Little Tennessee, sure I think you might be able to do $22K/yr, but not much more, unless perhaps the places are uniquely styled. 

But, it's a unique strategy that requires more knowledge than expected.

Be confident, be courteous, and time will teach you what works based on your unique personality and skillset.