In your case looking to larger assets where you can effeciently cost segregate to gather bonus depreciation would be a smart move.Appreciation - Where in the country is the asset class you like growing or going to be growingAmortization of the loan - What sector or even region if you look locally for funding, is going to offer the most favorable lending so that less goes to interest expense and more to pay down of principle.Have fun with a spread sheet comparing these 4 returns from your investment with the type and location of assets you find attractive. 

I want to start a nonprofit eventually to help the poor in the USA & other countries, and I'm considering using my own money or receiving government funds instead of relying on donations from people unless they're just rich ****s.

https://louisvilleky.gov/government/housing/lead-safe-louisv...

Its a process and a government process at that so be prepared for that.

@Ryan Raven most states don't care if you screw up the management of real estate you own personally.The government does have a problem with an unlicensed person/company screwing up the management of properties they do not own.

Quote from @Mitch Davidson: I haven't rented to FEMA, but I have rented to other government entities without issues.

There has been significant growth in the last 3-5 years, with booming business and real estate sectors.

I'm fine paying my fare share of taxes, but the government incentivizes us to do what it wants us to do - buy real estate, by giving us tax breaks.

Fannie and Freddie are the government sponsored enterprises- conventional loans are underwritten to their guidelines. 

It seems the only people who actually got loans from them were PPP loans from the government during Covid.