Depending on the lender and program your biggest hurdles might be credit score and income and time in job. 

For a nice possibly furnished STR, you are looking at between $250,000 to $350,000 depending on your budget. 

Mike It depends on the type of portfolio you have.

@Hsin-I Hsu  It depends on your long term goals, risk tolerance and earning potential.A couple of bay area sayings:   Any time you can afford to buy real estate you should.  

It also depends on state of the 6-unit property that you are interested in purchasing. 

I have heard that interest rates for a DSCR loan are generally 1-2% higher than conventional loans depending on the LTV ratio and credit score.

Hello @Kyle Luman,In the first few years, tax deductions like depreciation typically offset cash flow, depending on the rate of rent growth.I also want to comment on your statement: “Buy in appreciating areas.

Another thing to consider, most single family bedrooms rent for 800-1200 monthly depending on the area.

Depending on what type of investor you are or want to be, there are still deals out there.

Some of my clients love the cash flow in the east side neighborhoods over by Slavic Village and Broadway selling between 90-110k with rents up to $1,800+, but just really depends on the types of neighborhoods you're investing in and your risk / reward threshold.