I'd minimize the risk of having negative cash flow in the first 12 months when things are the most unknown and I'd be able to increase the gross rent of the property which should give me a better loan or at least bigger margins to cover my risk for negative cash flow. 

Too many unknowns.

You (and everyone) probably knows that standardized process of selling or buying a house; thus, the agent service is almost commoditized -- sure there are variances here and there with special needs, permits unknown, financial irregularities, unclear titles, etc...  

Whether bitcoin goes up or not is an unknown. 

Additionally, you could not move your Roth IRA funds into a Solo(k) because for some reason unknown to even the Department of Treasury (I asked them) Roth IRAs cannot transfer into the Roth bucket of a Solo 401(k).

In one instance I was told that the seller was expecting 92 to 94% of UPB, which was in that scenario equivalent to a 85% LTV, and I thought this was too high for the amount of risk and unknown involved.I would love to be buying these around 50 to 60% LTV but don t know if that s realistic currently?

But if you've got one or more day zero tenants to occupy all or part of the space, that could blunt the unknown in a big way.

As noted, it keeps capital available to replace the HVAC, when it goes out in your first month of ownership, or the roof starts leaking and you are chasing an unknown source to the tune of thousands of dollars.  

So many unknowns and very difficult to base it on average sq ft pricing.

@Karl Cameron ignoring the negative people goes along way in finding successes and stepping into the unknown.