@James Carlson & @Matthew Carroll
Those are some great points for sure! I actually really do like the area over by Pablo's coffee. Running north and south on Syracuse has a lot of potential. That whole space between Lowry and Stapleton is slowly turning over. However as you go east a bit on Colfax between Yosemite and Peoria, I personally would not want to live within 3-4 blocks of Colfax north or south.
I live a bit further away off Peoria and Mississippi. My set up is a 5 bed 3 bath house. I live in the master and have 4 unfurnished rooms that I rent out. I furnished the main areas and the kitchen. I have been doing my leases set up as month to month however, once people move in they tend to stay. I set it up this way for two reasons. First, it is an easy out incase of a non-compatible roommate. In my lease I state that I can give a tenant 30 day notice to leave for any reason. Second, I can ask for a higher rental rate that is justified by the month to month terms since no one is signing into a year long agreement.
Overall, I believe there is a lot of opportunity to be had around the Anschutz Medical Campus. As a five year outlook in my opinion, things in this area will look much better than they do now. It will be a completely new place. As for current time just be in touch with a knowledgable property management company or personally drive the area (day and night) to see how it is for yourself. One street over can make a lot of difference in that area.