@Matthew Otero - Here are the quick bullets I give my clients. Yes, you will save money in the long run with QB Desktop. However, I think the long term benefits of Online may be worth the value, and I would recommend it as the portfolio grows.
Also, keep in mind that this is not a permanent decision. You can usually migrate from one to the other without too much headache.
1) COST - QB Desktop is sold as a flat application cost ($200-$1,000) while QB Online is sold on a Software as a service (SAAS) model (monthly subscription $10-$150).
2) UPDATES - W/ QB Desktop you will need to buy the new version and upgrade to receive any updates. W/ QB Online, intuit rolls updates out routinely in the background.
3) PROTECTION - W/ QB Desktop you are responsible for the protection of your files (e.g., file backups, potential corruption, hardware issues). W/ QB Online Intuit guarantees against such risk.
4) ACCESS - W/ QB Desktop you generally can only access it from the installed computer. However, there are other services available that you can utilize to host virtually. W/ QB Online you can access anywhere with an internet connection and have access to a suite of mobile apps.
5) ASSISTANCE - W/ QB Desktop you will need to share the file with an accountant or consultant either through a secure portal or via physical delivery. W/ QB Online access can be granted to an accountant online in minutes.