I have a couple of these at a large SEC school and have been more than pleased. I disagree with the person who says location is overrated. Walking to class, bars, restaurants etc. is huge. Students seem to prefer the older houses that have location and character over the "purpose built" stuff that is more like a luxury dorm.
One of mine cash flows 13k / year and the other 8k. The first is a 5 BR / 3 BA but only1600 SF. The second is a 4/3 at 2300 SF. The biggest bonus that I did not anticipate is the market has gone through the roof in the past two years. Property values are way up to the point I have contemplated selling the second one because the return is not as great based on the current equity in the home. That's a nice problem to have though.
The down side in this town is it has become a sellers market and there are no more deals to be had. I wish I had started a couple years earlier and had 5 - 10 of these.
The key to me is having a good property management company that specializes in college rentals. Your expenses will still be higher than a family renting but so is your rent. The five BR I have rents for $600 / BR and they do 12 month leases. There is a turnover week the last week in July where the place is cleaned if new tenants are moving in.
Lastly I live a long way from these rentals and only go in them once a year. Again a good property management company is key here. Mine only charges 7% and they can do this because their properties are in such a concentrated area. I made initial improvements after purchase and the major items since then are usually HVAC issues or appliances going out.
Like many people I got into this when my kids went to school there buying a place for them and friends. However after seeing the returns this provides in comparison to the stock market I hope to shift more here and less in the market. I am also trying to buy locally but cannot find the returns in comparison to the college market. It's really the same problem as prices have risen much faster than rents.