We have done a lot of short-term renting in Colorado and do it with both VRBO and Airbnb. VRBO takes a higher cut upfront than Airbnb and you don't have the advantage of seeing guest reviews- which is a really nice feature on Airbnb that allows you to see if someone's a creep or not. I think both services are good, but in our area (at least) Airbnb tends to be a little more popular.
For both services, you'll need to handle key hands offs and cleaning. I think the key hand off could be managed with a good automated lock (there are a few strong options on line). If you ask a neighbor, I'd think about starting to comp them on some level.
Finding a dependable cleaner is really the biggest headache, and the most important. A lot of cottage industries have sprung up around this and specific to Airbnb. I think if you google a national Airbnb cleaning service, you should find someone that can help and runs it like a business. They will take a cut, but it'll be more than worth it in the long run.