These have all been great suggestions! I will add a couple of my own:
1) Do the paid version of AirDna wherever you are thinking of buying. BUT, don't always trust the data. For instance, in the paid version, you can see how much revenue a particular place has earned. However, sometimes it's not right. Look at how many reviews the place has. If AirDna says a home has made $70k in revenue, but there are only 3 reviews, it's probably not right.
2) Automate as much as you can. Get a digital lock that will automatically create each guest a code, automatically sends the guest an email with the code, and makes the code active only at the exact check in day and hour. I use Lockstate, and it works great, but there are others. Just this weekend, I had a guest try to check in the night before their reservation, and there were other guests there! Luckily, their code didn't work because it was too early, so they didn't get in.
3) To operate one property, you don't need a channel manager. List it on Airbnb and VRBO. That's all you should need. I get 98% of my bookings on Airbnb, and I run 95% occupancy. Channel Managers can be very complex with a huge learning curve. Add one later if you want.
4) While you don't necessarily need a channel manger, automating the guest messages is a HUGE reduction in workload. I use SmartBnB, and I love it! It sends several messages to the guests, from right after booking, the day before check in, the day after check in, the day before check out, and a day after check out. It also will automatically send a good review a couple of days after check out, unless you tell it differently. Huge time saver! It also automatically sends my cleaning team a request to clean on the check out date.
5) As the others have said, have a good cleaning team and handyman.
Best of luck!