Stephen - Risk is in the eye of the beholder. First, I would mention that there are guidelines setup for qualifying for those distributions. Granted they are relatively liberal, including being quarantined, being furloughed, being unable to work due to lack of child care, owning a business that is closed or under reduced hours and frankly any other reason the IRS decides it is ok. If you fall somewhere in that spectrum, then its certainly an option to consider if you could use the cash flow.
However, if your sole intention is to pull out cash to make a short term investment, I would certainly advise you to use caution. Three years may or may not be sufficient for your investment thesis to play out. More importantly, IRS taxes and penalties are nothing to joke about.
You may instead consider some version of a self-directed IRA if you wish to use your retirement assets to fund some kind of real estate endeavor. This would be within the normal confines of the law, and would at least reduced any of the above mentioned risks.
All things considered, its a rather complicated conversation to have via a public forum.
If you would like additional help, feel free to PM me.