Quote from @Taylor Dean:
Duplex vs 3/4 unit profitability all depends on the numbers. Are you buying a duplex for $150k or a 4 unit for 400k? The difference in the mortgage alone and how much you can make on rent will give you an idea of which would be better.
Overall great points and very helpful, thanks! As for the ^above^, the point I'm trying to get at is if having fewer doors in a significantly nicer neighborhood is a worthwhile tradeoff when trying to do a strategy besides LTR. It is easy to run the LTR numbers and decide off of that, but if I'm going after MTR, STR, student housing, or some other strategy to greatly boost cash flow, I'm curious how much of a difference the neighborhood makes and how to quantify that (again, not by LTR numbers). Rent coming from 3 units (4plex) instead of 1 (duplex) sounds way better on the surface, but if I'm trying to do MTR or similar, I don't want to be stuck with tons of vacancies.
My concern comes from David Greene and other top investors consistently warning against C class neighborhoods. Really I just want to ensure my first house hack is a successful one, especially in the long term.