Real estate can be a great tool for tax planning. However, a lot of those benefits come as the investments grow and not necessarily up front.
However, for a real estate professional it is possible to get huge write-offs immediately. For buy and holds, you are entitled to depreciate the full cost of the property (less the portion allocable to land), and not just the down payment (i.e. if you buy property for $1 million but only pay $200,000 the full $1 million is depreciable- as long as none of that is allocated to land). However, that is normally over 27.5 years or 39 years depending upon the type of property. If you get a cost segregation study though that identifies a significant percentage of the property is actually personal property with a 5, 7, or 15 year life you would be able to depreciate it much faster- perhaps even in the year of purchase with the new accelerated depreciation rules. So in that same example, if 20% of the building could be reclassified as personal property through a cost segregation study that means potentially there would be a $200k depreciation expense. That might mean a large tax write-off IF the owner is a real estate professional (otherwise passive loss rules apply).
Since your brother owns another business it is doubtful that he would be able to qualify as a real estate professional, but if he is married his spouse might. If his spouse qualifies as a real estate professional, they could purchase the commercial property the business is located at and rent it to the existing business at a fair rental rate. That MIGHT generate tax savings in the year of purchase.
NOTE: Your brother should talk to his CPA about this before considering doing it himself.