Renting to non citizens

[William George spear]

We are 2 years into rentals and are considering renting to a spanish couple that have been here over 20 years, have fin numbers and are gainfully employed. The husband has applied for a green card. the wife has not. What should I be considering other than the possibility of deportation? The current political climate in washington is another consideration. Would there be any legal rammifications to us  as the landlord.