Buying a larger multi unit vs several smaller multi units

[Rodney Sums]

I'm just curious from a general discussion point of view.  I understand it's all about the numbers and comparing the would be deals to give a definitve answer, and obviously it makes more sense to go with the option that produces more proft.  With that being said, generally speaking from those of you who have experienced both or had to decide between one or the other:

As an investor, compare and contrast the benefits/disadvantages if you had the same amount of resources to purchase several multiplexes with fewer units each vs one larger multiplex with many yet nearly the equivalent number of units (i.e. you can buy four 4-plexes or buy a 16 unit property with the same money)?  Again, generally speaking, and I understand it varies by market and prices and other variables etc....