Is it possible or inappropriate to bring this up to my agent and ask to reach out to the seller and explain the situation and propose a lower offer that I'd feel more comfortable offering if I went through with the deal and ended up losing my job and had to float the mortgage with savings?

Before you know it, you will be comfortable and ready to make moves on your first deal. 

For me, it would be a comfort level about the deal you’re getting.

@Michael King My experience has been that people who are looking to sell their homes don't feel comfortable listing.

I'm very comfortable with requiring my tenants to pay the rent, all the rent, that they agreed to.

I appreciate you sharing, I never think of my local credit unions, as I've become so comfortable with my go-to lenders.

If you are putting a 20% down payment you have comfort in knowing you still have equity in your home from the start.

I have had several people recommend that I do not disclose that I am the owner, but I never fully felt comfortable with that idea.

I was bored out of my mind at times but I got to do it from the comfort of my backyard on my own time.It took me about 5-6 weeks but if you're doing little else other than taking the course while home, you can be done in 1-2 weeks.My tips on taking the course would be to take down any notes as you go along the course so that you highlight anything that seems important or needs further research. 

You need to decide whether or not you are comfortable with investing in a home that has one.