Seeing this everyday I'm sure was a factor in my friends' brothers' delilberate demise.The renters helped me clean and paint beginning a few days before finishing yesterday. 

Could you rent your primary residence out if your job situation or other personal factors forced a move and have cash-flow? 

That sounds good until you factor in dealing with 15 different low income families , 15 hot water heaters , 15 roofs , property tax and water bills .

I know vacancy is a function of hundreds of factors, but in general, a property in close proximity to Ohio Stadium, downtown, the Convention Center, etc, - what is a conservative overall vacancy estimate for the year when used as an Air BnB type rental?

If not, you would likely need to account for that in your expenses. 2) I would make sure to factor in lawn care / snow removal (if applicable)3) Lastly, I would make sure to add insurance into your expenses.Otherwise, your numbers look good (although I cannot attest to your rent estimate as I do not know the area). 

What are your "minimum" factors to consider a property?

Any factor for anyone getting into real estate to really consider.

What are some of the factors to consider based off the circumstances and what questions should I be asking the listing agent ?

As long as you factor the interest rate you are eligible for when you are calculating your potential profits you should be okay.

Here is a great white paper on the topic published by Old Capital:https://www.wealthgrowinvestments.com/wp-content/uploads/2017/06/Multifamily-Financing-101-FINAL-2017.pdfAnother factor is getting a sense of the market for the debt of your project.