BP has some great articles with general information and tips:  https://www.biggerpockets.com/hubs/property-types/commercial 

While Keene is hardly a large metropolis, it is the most populated area in western NH and the hub of that part of the state, so the same holds. 

But let's be blunt, if things start to slow down in the worlds tech capital, that impact will be felt in other smaller tech hubs including Seattle and Austin and then they will have cascading impact on their surrounding areas.

I have always wanted to move out to a tech hub on the west coast, but the salary vs cost of living differential has never made sense to me.  

Obviously it would still be ideal to live nearby the entertainment hubs, but I imagine that if I was given the option of buying a much nicer house for half the cost (or renting), with these developments I would probably take it.

(our faces..hubs will be so disappointed if I royally screw us up!)

Also, if it is rural, it may need a hub to be steady.

Same could be said for any other large business hub internationally (Paris, Beijing, Tokyo, etc.). 

Because of the link between Tampa port - Miami port - Orlando hub alone makes Ocala a better search than areas such as Kissimee or Lakeland. 

Petersburg each have their own respective downtown hubs consisting of high-rise office buildings, high-rise luxury residential buildings and direct access to major highway systems.