Exclude or not to Exclude PO Boxes from Mailers

[Alex Bejenaru]

Ive been searching all over BP for the answer but all I see are a million threads about getting a PO Box for returned mail. 

I'm curious if people exclude mailing prospects if they have a PO Box as their mailing address for absentee owners. I'm setting a campaign for about 8,000 pieces a month and about 800 of the absentee properties go to an owner with a PO Box for their mailing address. Should I exclude or send them out?